Which anticholinergic agent is commonly associated with overdose?

• A. Diphenhydramine (Benadryl)
• B. Atropine
• C. Scopolamine
• D. Sertraline

Answer: (A)

Diphenhydramine, commonly known as Benadryl, is recognized for its anticholinergic properties and is frequently associated with overdose cases. This over-the-counter medication is an antihistamine that is often used for allergies, but in higher doses, it can lead to significant anticholinergic symptoms such as confusion, agitation, dilated pupils, flushed skin, urinary retention, and increased heart rate. The drug is widely available, which contributes to the potential for misuse and accidental overdose, especially in children.

Atropine and scopolamine, while also anticholinergic agents, are less commonly associated with overdose in the general population. Atropine is typically used in emergency medicine for specific indications like bradycardia, and scopolamine is often used for motion sickness; their clinical uses are more controlled, reducing the likelihood of seeing opioid-like overdoses in everyday practice. Sertraline, on the other hand, is an antidepressant and not primarily recognized for anticholinergic effects, making it less relevant in this context.

Understanding the likelihood of overdose events linked to specific medications helps in emergency responses and managing potential toxicologic scenarios effectively.