What two symptoms are often seen in patients with methamphetamine overdose?

• A. Hypotension and lethargy
• B. Hyperthermia and agitation
• C. Bradycardia and confusion
• D. Chest pain and weakness

Answer: (B)

In methamphetamine overdose, hyperthermia and agitation are commonly observed symptoms due to the stimulant nature of the drug. Methamphetamine causes an increase in metabolic rate and stimulates the central nervous system, leading to an elevation in body temperature, known as hyperthermia. This condition arises as the drug pushes the body's systems into overdrive, which can impair thermoregulation.

Agitation is also a prominent symptom as methamphetamine can induce intense feelings of restlessness, anxiety, or irritability. The drug heightens alertness and energy levels, which can manifest as hyperactive behavior or severe agitation.

In contrast, the other options present symptoms that are less characteristic of methamphetamine overdose. Lethargy may occur with other central nervous system depressants rather than stimulants. Bradycardia and confusion are typically associated with substances that depress the nervous system, while chest pain and weakness could result from various issues but aren't direct indicators of methamphetamine toxicity. Therefore, hyperthermia and agitation are key symptoms that align with the physiological effects of methamphetamine overdose.